Porton Biopharma, is working together with Public Health England and US company Blue Willow Biologics (previously NanoBio Inc.) to develop a next generation anthrax vaccine at PBL’s facilities in Porton, Wiltshire, UK. This programme is currently funded by the US Government, through its National Institute of Allergy and Infectious Diseases (NIAID). The total value of the contract (number HHSN272201600045C) could be worth up to £14million (US $24million) over its 8 year term, if all options are exercised.
If successful the next generation vaccine will combine the PBL’s expertise with anthrax vaccine antigens and US Company NanoBio Inc’s stabilisation technology enabling immunity to be achieved by fewer doses than current vaccines and by intra-nasal spray device instead of an injection.
Porton Biopharma Ltd (PBL) announced in June 2017 that it had signed a modification to its contract to cover the next phase of the programme. The contract modification is worth US$5.6 million.
Following successful preclinical results PBL announced in October 2019 that it had gained approval to advance the vaccine into phase 1 clinical trials.
PBL’s contract supports the advanced development of candidate vaccine components and technologies that accelerate the immune responses for use in post-event settings following the intentional release of the Category A priority pathogen Bacillus anthracis, the bacterium that causes the disease anthrax, or in response to naturally occurring outbreaks of the disease.
Commenting on the award, Dr Roger Hinton Managing Director of PBL said “We are delighted that we are able to progress into the clinical phase of the contract and this latest award is a recognition of all the hard work of staff at PBL and its partner Blue Willow, especially in writing, reviewing and gaining approval for the IND from the FDA.
This is a pivotal study that builds on the research and development that has been used to progress this novel product to date by PBL and its partners in collaboration with NIAID’s technical team. It is a recognition of the knowledge and expertise within the company and demonstrates the ability of PBL to further deliver on our track record of developing and manufacturing life-saving products for world-wide markets”.