Careers

Porton Biopharma has approximately 350 staff in a wide range of roles from those working in our pharmaceutical manufacturing plants, through to our quality and scientific development groups.  All focused on developing & manufacturing life-saving products that make a real difference to patients’ lives.

We are always looking for people, ranging from those with a general interest in science & technology, to ones with higher qualifications and/or experience.

This currently includes various vacancies for pharmaceutical production staff and supervisors to support our continued growth.  So if you are a motivated person who is interested in working in a high-tech environment as part of a dynamic team, then there could be a role for you.

 

 

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WE OFFER…

A friendly environment working alongside committed teams of people, who will be happy to share their knowledge and experience to allow you to develop your potential, with benefits that include:

  • a competitive salary
  • the necessary training
  • a pension scheme
  • 30 days annual leave
  • a canteen, gym and an active sports & social club
  • free on-site parking

With ongoing investment into the company and plans to increase our workforce, we are committed to being a leading life-science company that really makes a difference to patients’ lives.

To see the sort of  people that we ‘re looking for, the  Staff Profiles page has short interviews with current staff giving an overview of just some of our roles.

CURRENT VACANCIES…

PBL only accept CV’s from Recruitment Agencies with whom we have agreed Terms & Conditions.

A list of our current vacancies shown below.

To apply for a specific vacancy applicants should  send a covering letter quoting the Job Reference Number, a copy of their CV, together with a supporting statement referring to both the Job Description and Person Specification.

However, we also welcome applications from people with transferable skills that are looking for that next challenge and to develop their career.  To be considered for up-and-coming roles please send a covering letter indicating why you want to join PBL and in which area your career aspirations lie (Engineering  / Production  / Quality etc.),  along with a CV detailing your skills and experience which we can keep on file for when a suitable position becomes available.

All applications should be sent to recruitment@portonbiopharma.com.

WORK EXPERIENCE

As a business, we recognise the value that offering work-experience placements can bring and typically offer up to 4  one-week placements each year, usually in June.   All applicants must be over 16 years of age at the time of the placement, and will be chosen following a selection process.

If you are interested in applying, then send an email and covering letter stating your interest and giving reasons why we should choose you to business@portonbiopharma.com  Applications must be received by the end of November in order to be considered for the following summer’s places.

 

PBL407 Process Engineer

Salary: Circa £40,000 per annum

Reference Number: PBL407

Job Summary…

The Engineering group provides all engineering support within the highly regulated GMP production facilities at PBL Porton Down. The group includes engineering functions provided by predominantly chartered professional engineers specialising in clean rooms, GMP critical utilities, production equipment, pharmaceutical facilities, and capital works delivery.

The Process Engineer is the System technical expert for all Process and Utility systems within the GMP Envelope and is responsible for identification of and managing small projects/initiatives relating to these systems and interfacing with the wider Engineering group to ensure equipment systems within the GMP envelope remain compliant with current Good Manufacturing Practice. In addition, the Process Engineer will work within an Integrated Process Team to provide operational support to the manufacture of biopharmaceutical products.

The post holder will…

Be a core member of an Integrated Process Team and will provide operational engineering support to the manufacture of biopharmaceutical products alongside other core members from the Production and Quality functions. You will have delegated responsibility from the Process Engineering Manager to design, manage and deliver process improvement projects and represent the group in the delivery of major facility expansion/refurbishment projects.

You will become the Subject Matter Expert for a variety of systems and equipment such as Autoclaves and Critical Utilities (e.g. WFI, Clean Steam, and Purified Water) within the Pharmaceutical Production Envelope. As such you will interface with key stakeholders including equipment users, capital project managers, and the site principal maintenance contractor, to ensure these critical systems remain in compliance with best industry and regulatory practice.

We are looking for…

An applicant with experience of design or operation of process or utility systems in a highly regulated industry. The ideal candidate will have existing experience in the pharmaceutical industry. The individual will be either working towards or have recently become chartered with a supporting process or chemical engineering degree.

To download the job description please click here

PBL411 Aseptic Processing Specialist

Salary: Starting salary £29,355 negotiable dependent upon experience

Reference Number: PBL411

Job Purpose…

This position will report to the Aseptic Processing Functional Manager and will provide technical specialist support to all aseptic processing activities in the manufacture of Erwinase, Anthrax vaccine and other PBL products. The role will work cross functionally and be involved in current projects, new projects and all manufacturing activities that require aseptic processing input. It is expected that the role will typically focus on day to day aseptic processing matters within Production but may also be required to support projects designed to improve and develop PBL’s aseptic processing strategy.

We are looking for…

An individual who is educated to degree level or equivalent in a relevant discipline. The successful candidate should have a minimum of 5 years’ experience within Biopharma / Pharma aseptic GMP environments and have an in depth understanding of aseptic processing and techniques. You will need to have an understanding of regulatory requirements for biological products and experience in the implementation of new technologies and equipment into GMP manufacture and will have proven experience of generating GMP documents within a quality system. Experience of delivering specialised technical training and report writing and data trending evaluation would be desirable but not essential. The successful applicant will have a flexible approach to work and be able to deliver to schedules.

The post holder will…

  • Lead in the day to day aseptic processing of PPL’s products.
  • Support the management and development of improved and new processing techniques in the various aseptic processing activities.
  • Provide technical support to production staff involved in the various aseptic processes.
  • Provide troubleshooting and technical support into process investigations.
  • Collate and share technical information with internal and external bodies to benefit the production methods, teams and departments.
  • Perform process mapping and process efficiency trending.
  • Provide specialist training to staff in aseptic processing techniques and theory.
  • Identify, evaluate and adapt new technologies where appropriate and ensure that the production area operates to a high standard and complies with GMP and other regulatory standards.
  • Assist colleagues in providing technical specialist input as required, in developing production and technical strategies for the units, identifying new opportunities as they arise and responding to external queries and complaints.
  • Contribute to reports and assist on the preparation of presentations, publications and liaison with customers, collaborators and licensing agencies.
  • Support the Functional Manager Aseptic Processing in pursuance of strategic improvements to aseptic processing control.

To apply for this position please submit a CV and cover letter using the criteria in the job description/person specification as sub-headings to identify how you meet each of the selection criteria and outline why you would like a career at Porton Biopharma Ltd.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer

We reserve the right to close this vacancy should a suitable candidate be found.

To download the job description please click here

PBL442 Computer System Validation Specialist

Salary: Starting salary £42,230 negotiable dependent upon experience

Reference Number: PBL442

Job Purpose

This role is within the Facilities Validation Department and is responsible for the provision of subject matter expertise and the execution of Computerised System Validation activities.The Facilities Validation department supports cGMP manufacturing activities and is responsible for ensuring compliance to the cGMP guidelines.

This role reports into the Computer Systems Validation Manager and is responsible for the timely execution of Computer Systems Validation activities with respect to:

  • Writing (and reviewing) of validation protocols
  • Timely execution of CSV protocols with the subsequent generation of reports
  • Leading CSV compliance investigations with respect to Non-conformances and CAPAs
  • Performing CSV / Data integrity gap analysis and remediation activities.

The post holder will be expected to write, review and approve validation protocols, execute validation studies and write, approve validation reports associated with the qualification of Computerised systems and the introduction of new equipment into beneficial use.

The post holder will…

  • Take the lead in computer system validation and compliance, manage and deliver specific Validation Projects according to the business priorities, including work scheduling and supervision of junior members of staff.
  • Promote continuous improvement of validation systems and procedures to ensure efficiency and best practice within the industry and to stay abreast of changing regulatory expectations.
  • Write, review and approve validation documentation including protocols and reports and manage the timely closure of any discrepancies or non-conformities
  • Provide a reliable service to our internal customers to ensure that timescales are met, and work is carried out to meet expectations.
  • Maintain the ongoing compliant status of computer systems associated with equipment, facilities and utilities by involvement of the scheduling of activities.
  • Communicate validation activities with our internal and external customers and work with them to resolve problems and conflicts.
  • In line with overall responsibilities, perform additional tasks assigned by the line manager.
  • Undertake all work in accordance with Code of Safety Practice and site Quality Policies.

We are looking for…

The successful candidate will be educated to BTEC National Certificate level including Science or equivalent qualification or significant equivalent experience. A BSc in Engineering, Science or IT would be desirable but is not essential. You will need to have substantial experience of generation, execution and review of validation protocols, reports and technical documents as well as experience of validation life-cycle activities for computerised systems. The successful applicant will have extensive practical experience of working within a GMP quality system. Practical experience of working within a biopharmaceutical manufacturing environment would be desirable.

This is a hands-on role in a dynamic operating environment and the ideal candidate should be self-driven and capable of organising their own work-load. They should be comfortable liaising with stake-holders in order to deliver an effective documentation to an agreed time line and be confident to supervise junior staff.

For further information about the post, please contact: kevin.smart@portonbiopharma.com

To download the job description please click here

PBL485 QC Technologist (Monitoring and Training)

Salary: Starting salary £23,735 per annum negotiable dependent upon experience

Reference Number: PBL485

Job Purpose…

To provide specialist training in microbiological environmental monitoring methods, cleanroom gowning, aseptic practices and water sampling. The successful candidate will also be required to undertake microbiological environmental monitoring of critical pharmaceutical manufacturing operations to support the Sterility Assurance Program. To supervise, oversee, observe and qualify all production technologists and other staff where applicable, in gowning, microbiological environmental monitoring methods and water sampling.

We are looking for…

A candidate who has previous experience of working in cleanrooms, performing environmental monitoring and training of other members of staff to join the Environmental Monitoring Team within QC Biological Services. A degree in a relevant scientific discipline is desirable but not essential. The candidate should also have a good understanding of QC Microbiology laboratory testing. Applicants must have a flexible approach to working and be able to comply with SAPO regulations and must have a current valid right to work in the UK.

The post holder will…

  • Operate in compliance with cGMP.
  • Train and qualify all Production and other staff, as necessary, in the techniques and procedures for microbiological environmental monitoring.
  • Train and qualify all Production and other staff, as necessary, in water sampling.
  • Train and qualify all Production and other staff, as necessary, in procedures for gowning.
  • Oversee, supervise and observe Production and other staff undertaking environmental monitoring and water sampling to ensure continued compliance.
  • Re-qualify Production and other staff at a defined frequency, as required by GMP.
  • Plan and organise schedules for training, qualifications and observations.
  • Assess staff competence in environmental monitoring, water sampling and gowning procedures. Sign training documentation and produce certificates for trained members of staff.
  • Carry out and record microbiological environmental monitoring for critical manufacturing operations, and routine monitoring where required.
  • Input microbiological environmental monitoring and water sampling data into appropriate databases and spreadsheets.
  • Be involved in the writing and updating of Standard Operating Procedures relating to environmental monitoring and water sampling, either as the author, or by providing technical information and advice to the author.
  • Attend training courses that contribute to the efficiency of the operating systems and are beneficial to the post holder’s personal development.
  • Follow operating procedures at all times and ask for advice when necessary.
  • Undertake all work in accordance with Porton Down’s Code of Safety Practice and Quality Systems.
  • To prepare environmental summary reports of production processes for insertion into documents, reports and batch manufacturing records as part of batch release.
  • To investigate out-of-specification water and environmental monitoring test results in conjunction with the Compliance Team and review resulting Non-Conformances, participating in Ishikawa and 5-Whys investigations, where necessary.

For further information about the post, please contact:

recruitment@portonbiopharma.com

To apply for this position please submit a CV and cover letter using the criteria in the job description/person specification as sub-headings to identify how you meet each of the selection criteria and outline why you would like a career at Porton Biopharma Ltd.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer.

We reserve the right to close this vacancy should a suitable candidate be found.

To download the job description please click here

PBL498 Validation Technologist (Facilities & Utility)

Salary: Starting Salary £29,335 negotiable dependent upon experience.

Reference Number: PBL498

Job Purpose…

The Facilities Validation department supports cGMP manufacturing activities and is responsible for ensuring compliance to the cGMP guidelines on Validation activities.

The purpose of this role is to execute validation activities relating to Facilities and Utilities. This will involve coordination with Engineering, Production, QC and QA departments to ensure a timely delivery of the qualification report.

The post holder may be expected to supervise contractor resource where appropriate with responsibility to ensure adequate training and supervision is provided.

The post holder will be required to write, review and where appropriate approve validation reports prior to execution, followed by report generation. The core activities will include thermal and microbiological testing of:

  • Autoclaves (BSEN-285)
  • Depyrogenation ovens
  • Extraction Tanks
  • Centrifuges
  • Vessels
  • (but not limited to) the qualification of Facilities and Utilities.

The post holder will...

  • Generate, review (technical) and execute process validation protocols (thermal and microbiological testing)
  • Create Process validation reports
  • Use the Electronic Quality Management System (EQMS) to manage appropriate corrective action plans and report through the PBL non-conformance system, for failures/performance issues.
  • Write and review Risk assessments
  • Manage work schedule as planned by the validation schedule co-ordinator
  • Coordinate Contractor or permanent resources to deliver timely documentation in support of Process Validation activities
  • Ensure Process Validation procedures are aligned with regulatory requirements
  • Meet all internal regulatory training requirements (internal training provided)

We are looking for...

A person with at least 12 months hands-on validation experience, able to perform thermal mapping studies and write protocols and reports. A sound knowledge of the Validation Life cycle and documentation deliverables is an essential requirement.

Other
In addition to Utilities and Sterilisation validation activities the post holder will be expected to undertake any related validation activities deemed necessary by line management. This could include the generation of validation documentation in accordance with the full validation life cycle for equipment, utilities and facilities.

For further information or an informal discussion about the post, please contact:

recruitment@portonbiopharma.com

To apply for this position please submit a CV and cover letter using the criteria in the job description/person specification as sub-headings to identify how you meet each of the selection criteria and outline why you would like a career at Porton Biopharma Ltd.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer.

We reserve the right to close this vacancy should a suitable candidate be found.

To download the job description please click here

PBL508 QC Technologist

Salary: Circa £23,500 per annum, dependant on experience & 7% shift allowance

Closing Date: 13th December 2019

Reference Number: PBL508

Job Summary…

A crucial part of the pharmaceutical production process is undertaken by the Quality Control Department, which performs chemical and biochemical testing to ensure that the manufactured product is safe, efficacious and fit for patient use as a pharmaceutical material. The QC Technologist is primarily responsible for testing of in process and finished product samples, to defined specifications while ensuring that work performed within the laboratories is carried out in accordance with the statutory requirements of current GMP and corporate statutory health and safety requirements. The QC Technologist is also responsible for the authoring of technical documentation and liaising with external laboratories to arrange contract testing of products.

The post holder will be required to work shift rotation. This rotation includes 2 weeks out of 8 weeks where the shift is 2-10pm and potential weekend working (schedule dependent).

We are looking for…

The ideal candidate will be educated to degree level or equivalent qualification in Chemistry, Biochemistry or other related subject. The successful candidate will have working knowledge or experience within a regulated or Good Manufacturing Practice (GMP) environment. Experience in biopharmaceutical analysis and analytical chemistry is desirable in one of the following areas; Water analysis, TOC, physical testing, UV-Vis or pharmacopoeia testing within a GMP compliant QC laboratory. Other key skills include the ability to work to deadlines, technical report writing, problem solving, the ability to work as part of a project team and good computer literacy.

 The post holder will…

  • Ensure analysis and recording of QC and stability testing is performed in compliance with the statutory requirements of cGMP.
  • Be responsible for testing in process and finished product samples to ensure that they meet the specifications established in the product licence and internal Porton Biopharma specification documents.
  • Be responsible for writing Standard Operating Procedures and their associated risk assessments to ensure that those tasks are performed safely, and other quality documents e.g. change controls, validation reports, non-conformances and CAPAs where appropriate.
  • Organise and liaise with external testing laboratories to arrange correct and on time testing to meet production deadlines or suppliers of equipment or chemicals.
  • Organise and liaise with internal departments such as validation, pharms stores and QA where required.
  • Maintain an up-to-date awareness of regulatory and scientific developments via courses, meetings and literature.
  • Undertake work in accordance with Porton Biopharma’s Code of Safety Practice and Quality Systems.
  • Maintain training records.
  • Cleaning of laboratories.
  • Performing maintenance and calibration of equipment.

For further information about the post, please contact:

recruitment@portonbiopharma.com

To apply for this position please submit a CV and cover letter using the criteria in the job description/person specification as sub-headings to identify how you meet each of the selection criteria and outline why you would like a career at Porton Biopharma Ltd.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer

To download the job description please click here

PBL509 Technical Support Specialist (Fermentation)

Salary: Circa £36,460 negotiable dependent upon experience

Reference Number: PBL509

Job Summary…

The Technical Support Specialist reports directly to the Technical Operations Manager. This position is a technical role primarily to support and improve the processes, policies, people and procedures associated with the manufacture of products at PBL. The Technical Support Specialist will have an excellent knowledge and significant experience in the field of fermentation and actively participate or lead in identifying and bringing into use new technologies, investigate and resolve technical issues, generate reports, protocols and other GxP documentation and provide technical input, advice and training as appropriate.

The post holder will…

  • Lead in the day to day fermentation processing of PBL’s products.
  • Support the management and development of improved and new processing techniques in the various fermentation processing activities.
  • Provide technical support to production staff involved in the various fermentation processes.
  • Provide troubleshooting and technical support into process investigations.
  • Collate and share technical information with internal and external bodies to benefit the production methods, teams and departments.
  • Perform process mapping and process efficiency trending.
  • Provide specialist training to staff in fermentation processing techniques and theory.
  • Identify, evaluate and adapt new technologies where appropriate and ensure that the production area operates to a high standard and complies with GMP and other regulatory standards.
  • Assist colleagues in providing technical specialist input as required, in developing production and technical strategies for the units, identifying new opportunities as they arise and responding to external queries and complaints.
  • Contribute to reports and assist on the preparation of presentations, publications and liaison with customers, collaborators and licensing agencies.
  • Support the Unit Manager in pursuance of strategic improvements to processing control.

We are looking for…

 An individual with significant relevant fermentation experience and proven practical experience of working within a fast-moving Good Manufacturing Practices (GMP) environment. The role will require the individual to have an understanding of regulatory requirements for biological products and have specific training and experience in fermentation production methods in a pharmaceutical environment. The successful candidate will be highly flexible and capable of managing several activities simultaneously, have excellent problem solving skills, strong technical writing ability, project management and hands on experience of Fermentation and Aseptic processes are essential.

For further information or an informal discussion about the post, please contact:

recruitment@portonbiopharma.com

To apply for this position please submit a CV and cover letter using the criteria in the job description/person specification as sub-headings to identify how you meet each of the selection criteria and outline why you would like a career at Porton Biopharma Ltd.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer

To download the job description please click here

PBL522 Senior Production Technician - FPP

Salary: Starting salary £21,000 per annum, plus 30% shift enhancement

Reference Number: PBL522

Job Purpose…

This is a shift working role which will attract a salary enhancement once appointed. This Senior Production Technician post is located at Porton Down in the Fermentation Process Plant (FPP) current Good Manufacturing Practice (cGMP) pharmaceutical manufacturing facility. This facility produces therapeutic products by bacterial fermentation followed by initial phase downstream processing.

Therapeutic products produced at Porton are licensed and marketed for worldwide distribution. The FPP is undergoing significant investment and expansion as production is being increased to meet product demand.

We are looking for…

An applicant who has GCSE’s in Maths, English and Science or equivalent qualifications. In addition, they should also be educated to a minimum of NVQ level 2 in a relevant subject or have significant equivalent proven experience. Candidates should have an interest in working within a manufacturing environment and with the Quality systems associated with cGMP manufacture. They should be able to communicate clearly, possessing good writing and data entry skills. Lastly applicants should be able to work effectively as part of a team, be proactive and able to work on their own initiative when required.

The post holder will…

Work a shift pattern which covers 24-hour, 7 day working. They will report to the Production Supervisor and will support the Production Supervisor to meet team targets by ensuring manufacturing operations are performed in a timely and compliant manner to cGMP requirements.

This role will involve undertaking a varied range of tasks, from preparation and use of operational equipment such as large scale fermenters and centrifuges, to preparation, completion, and review of Quality documentation. Full training will be provided.

Successful applicants must either hold, or be capable of obtaining, a UK government security clearance at SC level.  To obtain clearance at this level you must have been resident in the UK for the last five years, and not lived abroad for more than six months out of the last twelve.

For further information about the post, please contact: recruitment@portonbiopharma.com

Applicants are strongly advised to use the criteria in the job description/person specification as sub-headings in their application to make it clear how they meet each of the selection criteria.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer

To download the job description please click here

PBL537 Cleaning Validation Technologist

Salary: Circa £35,000 negotiable dependant on experience.

Reference Number: PBL537

Job Summary...

The Cleaning Validation team within the Validation Department supports the development and validation/qualification of manufacturing equipment cleaning processes. This includes both the validation of new or amended cleaning processes, and the ongoing routine cleaning verification of existing and validated cleaning processes.

This role is to execute the timely completion of cleaning validation studies in support of PBL manufacturing activities and regulatory requirements. The role will include the writing, review and execution of cleaning validation/verification protocol documents and reports, the coordination of support activities and resources to deliver on time a high standard of documentation.

The position holder will be expected to attend project group meetings, liaise with PBL support teams and peers to establish data for inclusion within protocols and reports.

The position holder should be prepared to execute and witness cleaning validation/verification studies in line with the Production schedule.

There will be a requirement to support other validation activities (e.g. Process Validation) on a temporary basis.

 The post holder will...

  • Write, review and execute cleaning validation/verification protocol documents.
  • Write cleaning validation/verification reports, where required.
  • Write, review and execute cleaning development documentation.
  • Deliver assigned cleaning development, validation and verification activities on time in accordance with the Site Validation Master Plan (VMP).
  • To deliver on non-conformance, action item, change control (CC) and CC actions on time.
  • Participate in assigned GEMBA meetings/activities, as required

We are looking for...

An enthusiastic candidate who can communicate effectively at all levels, and across multi-disciplinary teams, to support the completion of cleaning validation and cleaning verification activities to satisfy compliance and regulatory commitments, in addition to the continuous improvement of equipment cleaning processes at PBL.

For further information or an informal discussion about the post, please contact:

recruitment@portonbiopharma.com

To apply for this position please submit a CV and cover letter using the criteria in the job description/person specification as sub-headings to identify how you meet each of the selection criteria and outline why you would like a career at Porton Biopharma Ltd.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer.

 

To download the job description please click here

PBL540 Waters Analytical QC Manager and Stability Unit Manager (Fixed Term 18mth)

Salary: Circa £36000.00 per annum plus 7% shift allowance

Reference Number: PBL540

Job Summary...

To lead and manage a specialist GMP analytical chemistry/biochemistry laboratory to provide compliant testing of licensed pharmaceutical products; plus validation of analytical methods and expert support and advice to GMP product teams. This position will lead approximately 7 staff consisting of Senior QC Analysts, QC Analysts and QC Technicians performing essential analysis. The team tests routine water samples to EP and USP requirements and also supports in-process testing of biopharmaceutical products. In addition, the role is responsible for running a compliant stability program.

The post holder will...

Lead the Water testing and Stability teams within Quality Control Analytical including line management responsibility. The role will also support in-process testing of biopharmaceutical products and lead the stability program.

 We are looking for...

A motivated individual who is experienced in leading a team and has extensive knowledge of analytical techniques and the requirements of a stability program. The successful candidate will be experienced in using quality management systems in the pharmaceutical industry and will be able to work to tight deadlines.

To apply for this position please submit a CV and cover letter using the criteria in the job description/person specification as sub-headings to identify how you meet each of the selection criteria and outline why you would like a career at Porton Biopharma Ltd.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer

To download the job description please click here

PBL542 QC Microbiology Compliance Officer

Salary: Circa £27,000 per annum, dependant on experience

Job Purpose / Summary

The purpose of this role is to provide support for the QC Microbiology department at Porton Biopharma. This will include compilation of compliance documentation, including deviations, non-conformances and CAPA, change controls, protocols and reports. The holder will also to undertake and perform microbiological QC analyses in compliance with cGMP.

The post holder will…………

  • Write and review Standard Operating Procedures, protocols and reports in accordance with regulatory requirements.
  • Investigate, write and review non-conformances and deviations raised in accordance with regulatory requirements.
  • Complete departmental CAPAs and to implement any required quality improvements that may arise from this.
  • Identify and implement quality improvements within the department pro-actively.
  • Carry out change management, raising, writing and reviewing change controls.
  • Assist as a member of the QC Microbiology Team, on a day to day basis, of the Bacteriology Technical Services Unit.
  • Test microbiological samples, working at ACDP Containment level 2 and at Containment Level 3, when required, from all stages of the production processes of products manufactured at PBL, Porton Down and to assess the results against pre-set standards.
  • Record and assess results from environmental and water sampling and carry out preliminary and confirmatory identification of micro-organisms.

 We are looking for……………….

A candidate with significant experience of working to cGMP, with a significant knowledge of pharmaceutical Quality Assurance. The candidate must have experience in writing and reviewing discrepancies, procedures, change controls and CAPAs. The candidate should have a significant level of experience of working within ACDP containment level 2 microbiology laboratories.

To apply for this position please submit a CV and cover letter using the criteria in the job description/person specification as sub-headings to identify how you meet each of the selection criteria and outline why you would like a career at Porton Biopharma Ltd.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer

To download the job description please click here

PBL549 Development Placement Student

Salary: £20,000 per annum

Closing Date: 20th December 2019

Reference Number: PBL549

Job Summary

The Development Group is a development and technology transfer group playing a key role in the translational research activities of the site. Its role is to develop manufacturing processes and associated analytical methods for use in the cGMP production of biotherapeutics and healthcare interventions. Projects may comprise the development of research designs and/or the improvement of existing commercial processes. The department is organized into 4 core teams with responsibility for product development, in vitro culture processes, downstream purification processes and analytical method development.

The post-holder will contribute to the activities of the group by providing support in the development of production processes for biopharmaceutical products within ISO 9001 laboratories.

We are looking for an individual with an interest in a number of scientific and technical skills the area of the cloning, culturing and growth of prokaryotic organisms, downstream processing and biological assay development.The post holder will be currently enrolled in, and have completed the second year of a science degree in a relevant biological science at a university that supports placement students.

For further information or an informal discussion about the post, please contact:

Dr Dave Gervais 01980 551759

Applications should be e-mailed, along with a covering letter explaining your interest in the role, to dave.gervais@portonbiopharma.com. We also strongly suggest including with your application a letter of reference from an academic tutor explaining your suitability for the placement.

Applicants are strongly advised to explain in their application both their interests in the role, and how they meet criteria described above.

Please note that we are not accepting applications from recruitment agencies for this post.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer

To download the job description please click here

PBL552 Senior Analytical Scientist

Salary: £25,000 - £30,000 per annum

Closing Date: 2nd January 2020

Reference Number: PBL522

Job Summary…

The successful applicant will join the Analytical Method Development Team, which develops and performs analytical methods to support the manufacturing of biopharmaceutical products. These methods are used to characterise existing manufacturing processes, to guide process improvements and to support the introduction of new processes. 

The post holder will…

The post holder will be involved in leading the development, optimisation, validation and implementation of analytical methods for existing and pipeline products. The post holder will also be responsible for coordinating technical transfer of assays to QC and supporting routine testing activities of samples provided by other groups within PBL.

The post holder will be expected to work to a testing schedule and meet determined deadlines using established methods; evaluate and optimise novel approaches; plan their own work; train and support junior members of staff; present and provide written and verbal updates and follow departmental policies and procedures.

We are looking for…

The applicant must be educated to at least degree level in a relevant subject. They will need to have hands-on experience of developing, optimising, validating and implementing protein analysis methods, ideally in a biopharmaceutical setting. Familiarity with a broad range of protein sample preparation and analytical methods is required. Examples of relevant techniques are: immunoassays; 1D and 2D-gel electrophoresis; enzyme activity assays; HPLC, UPLC and UV/VIS spectroscopy; and sample concentration methods. Experience of preparing technical documentation such as standard operating procedures, protocols and reports is required. The successful candidate will also be expected to maintain up-to-date knowledge of ISO, ICH guidelines, Federal Codes and other regulatory guidance relating to analytical methods and therefore awareness of the requirements of European and US cGMPs is highly desirable.

For further information or an informal discussion about the post, please contact:

Dr Claire Cherrett (Claire.Cherrett@portonbiopharma.com) Dr Alka Bishop (Alka.Bishop@portonbiopharma.com).

To apply for this position please submit a CV and cover letter using the criteria in the job description/person specification as sub-headings to identify how you meet each of the selection criteria and outline why you would like a career at Porton Biopharma Ltd.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer.

To download the job description please click here

PBL556 Manufacturing Unit Supervisor

Salary: Starting salary £23,735 negotiable dependent upon experience

Closing Date: 3rd January 2020

Reference Number: PBL556

Job Summary

The position is in the Immuno team who produce Anthrax Vaccine. The successful applicant will be responsible for supervising the manufacturing unit where the fermentation and filtration of Bacillus anthracis takes place and will be responsible that the unit is kept to GMP compliant standards and all daily housekeeping tasks are carried out. You will be responsible for 4 members of staff and will report to the Unit Manager.

The post holder will…

  • Carry out duties involved in the manufacture of biopharmaceuticals to cGMP standards.
  • Ensure that the facility is maintained in a compliant state and that the product/materials are manufactured to appropriate regulatory requirements.
  • Be responsible for data collection throughout the process.
  • Responsible for the provision of all consumables, supplies, etc. required for the process and documented storage of materials generated.
  • Manage and support junior staff in all their activities and ensure they are adequately trained in all operational processes.
  • Recognise the areas and individuals in your team where support is required. Ensure support is given either directly or via an escalated route.
  • Manage, oversee and support junior staff in all their activities and ensure they are adequately trained in all operational processes and that GMP Compliant behaviours are reinforced by all.
  • Work with the Unit Manager and Team Leader to develop, implement and perform internal self -inspections for the area to ensure that they are clearly communicating the expectations of GMP to all of their staff.
  • Responsible for ensuring that all staff adhere to, and all operations are carried out to, strict GMP guidelines.
  • To undertake all necessary training to enable the post holder to carry out his/her duties to the required standard.
  • Assist the Unit Manager/Team Leader in the completion of annual and six-monthly appraisals.
  • Ensure routine one two one discussions take place and are documented
  • Generate and review documentation with regard to risk assessments and cGMP, e.g. SOPs, to ensure compliance of the Unit with all necessary regulations. Complete documentation and records accurately and to a high standard.
  • To assist in the raising, execution and implementation of CAPAs and change controls.
  • Assist in the completion of non-conformance investigations
  • Required to work extended hours on critical processing days.
  • Perform a wide range of routine and some non-routine technical procedures and understand the rationale behind the procedures and practices.
  • To undertake work in accordance with PBL Health and Safety Policies and procedures and to work within any Quality systems that are appropriate to the site.

We are looking for…

A candidate who holds a HNC or equivalent qualification, a degree or equivalent qualification and a supervisory or management qualification would be desirable but are not essential. You will need to have knowledge of GMP requirements and how to implement them and have experience with training other members of staff. Previous experience of writing, reviewing and collating documents is desirable as well as having an understanding of various regulatory requirements. The successful candidate will have excellent communication and interpersonal skills and be able to work effectively as part of a team.

We are looking for a well organised person with previous GMP and supervision experience.

For further information or an informal discussion about the post, please contact:

Graham Douglas on 01980 557102 or graham.douglas@portonbiopharma.com

To apply for this position please submit a CV and cover letter using the criteria in the job description/person specification as sub-headings to identify how you meet each of the selection criteria and outline why you would like a career at Porton Biopharma Ltd.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer.

To download the job description please click here