Careers

Porton Biopharma has approximately 400 staff in a wide range of roles from those working in our pharmaceutical manufacturing plants, through to our quality and scientific development groups.  All focused on developing & manufacturing life-saving products that make a real difference to patients’ lives.

We are always looking for people, ranging from those with a general interest in science & technology, to ones with higher qualifications and/or experience.

This currently includes various vacancies for pharmaceutical production staff and supervisors to support our continued growth.  So if you are a motivated person who is interested in working in a high-tech environment as part of a dynamic team, then there could be a role for you.

 

 

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WE OFFER…

A friendly environment working alongside committed teams of people, who will be happy to share their knowledge and experience to allow you to develop your potential, with benefits that include:

  • a competitive salary
  • the necessary training
  • a pension scheme
  • 30 days annual leave
  • a canteen, gym and an active sports & social club
  • free on-site parking

With ongoing investment into the company and plans to increase our workforce, we are committed to being a leading life-science company that really makes a difference to patients’ lives.

To see the sort of  people that we ‘re looking for, the  Staff Profiles page has short interviews with current staff giving an overview of just some of our roles.

CURRENT VACANCIES…

PBL only accept CV’s from Recruitment Agencies with whom we have agreed Terms & Conditions.

A list of our current vacancies shown below.

To apply for a specific vacancy applicants should  send a covering letter quoting the Job Reference Number, a copy of their CV, together with a supporting statement referring to both the Job Description and Person Specification.

However, we also welcome applications from people with transferable skills that are looking for that next challenge and to develop their career.  To be considered for up-and-coming roles please send a covering letter indicating why you want to join PBL and in which area your career aspirations lie (Engineering  / Production  / Quality etc.),  along with a CV detailing your skills and experience which we can keep on file for when a suitable position becomes available.

All applications should be sent to recruitment@portonbiopharma.com.

WORK EXPERIENCE

As a business, we recognise the value that offering work-experience placements can bring and typically offer up to 4  one-week placements each year, usually in June.   All applicants must be over 16 years of age at the time of the placement, and will be chosen following a selection process.

If you are interested in applying, then send an email and covering letter stating your interest and giving reasons why we should choose you to business@portonbiopharma.com  Applications must be received by the end of November in order to be considered for the following summer’s places.

 

PBL442 Computer System Validation Specialist

Salary: CIRCA £42,230 per annum, dependant on experience

Closing Date: 14th August 2020

Reference Number: PBL442

Job Summary

 The Validation team comprises of approximately 30 specialists on a permanent or contractual basis. The scope of Validation activities for the team covers general re-qualification of equipment, facilities and utilities with an experienced knowledge base of Computer System Validation, Cleaning Validation, Process Validation and the delivery of capital equipment into beneficial use.

This role within the Validation team is necessary to manage and execute validation activities associated with the cGMP compliance of computerised and software systems, ensuring that they are appropriately qualified and fit for operational use.

The role will ensure that the commercial risks associated with disaster recovery and data life cycle compatibility are addressed for each computer system guaranteeing long term availability of business-critical systems and data.

This role is a hands-on position and requires the post holder to be able balance multiple project-based activities, coordinating the generation, review and execution of validation protocols with the relevant stake-holders.

In addition, this role will have an input into CAPEX projects where there is a significant computerised / software content, ensuring that systems have been appropriately designed and qualified to ensure effective and cGMP compliant operational use.

To lead and execute CSV validation activities of computerised systems and associated equipment in accordance with current regulatory requirements.

To minimize business risk associated with the processing and storage of electronic documentation ensuring continuity over the equipment and product’s life cycle.

The post holder will have the following duties and responsibilities;

  • Take the lead in computer system validation and compliance, manage and deliver specific Validation Projects according to the business priorities, including work scheduling and supervision of junior members of staff.
  • Comfortable working alone or within the matrix management system.
  • Continuous improvement of validation systems and procedures to ensure efficiency and best practice within the industry and to stay abreast of changing regulatory expectations.
  • Write, review and approve validation documentation including protocols and reports and manage the timely closure of any discrepancies or non-conformities.
  • Providing a reliable service to our internal customers to ensure that timescales are met and work is carried out to meet expectations.
  • Maintaining the ongoing compliant status of computer systems associated with equipment, facilities and utilities by involvement of the scheduling of activities.
  • Communicating validation activities with our internal and external customers and working with them to resolve problems and conflicts.
  • In line with overall responsibilities, perform additional tasks assigned by the line manager.
  • Undertake all work in accordance with Code of Safety Practice and site Quality Policies.

 We are looking for someone with the following skills, knowledge and experience;

 Essential

  • General education to BTEC National Certificate or equivalent, including science.
  • Substantial experience of generation, execution and review of validation protocols, reports and technical documents.
  • Experience of validation life cycle activities for computerised systems.
  • Substantial practical experience of working within a GMP quality system.
  • Experience of dealing with internal customers, identifying and delivering work programs, reporting progress and dealing with issues.
  • A comprehensive understanding of EU and FDA regulatory requirements relating to validation including (but not limited to) UK/EU GMP Annex 11 and 21 CFR Part11.
  • An understanding of GAMP processes.
  • Technical understanding of computerised systems including PLCs, SCADA, networked systems, laboratory systems, databases, layered software as used in a GxP environment.

Desirable

  • BSc in Engineering, Science or IT.
  • Experience of working with product Serialisation qualification.
  • Practical experience within a biopharmaceutical manufacturing environment.
  • Practical experience dealing with internal and external audits, including regulatory agencies, inspectors and auditors.
  • Understanding of the implementation risk in a site wide validation approach.
  • Critical assessment of reports and technical documents against customer and regulatory specifications and standards.

 

To apply for this position please submit a CV and cover letter using the criteria in the job description/person specification as sub-headings to identify how you meet each of the selection criteria and outline why you would like a career at Porton Biopharma Ltd.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer

To download the job description please click here

PBL498 Validation Technologist

Salary: Circa £29,355.00 per annum, dependant on experience

Closing Date: 14th August 2020

Reference Number: PBL498

Job Summary

The Facilities Validation department supports cGMP manufacturing activities and is responsible for ensuring compliance to the cGMP guidelines on Validation activities.

The purpose of this role is to execute validation activities relating to Equipment (Process and Sterilisation), Facilities and Utilities. This will involve coordination with Engineering, Production, QC and QA departments to ensure a timely delivery of the qualification activities and documentation.

The post holder may be expected to supervise contractor resource where appropriate with responsibility to ensure adequate training and supervision is provided.

The post holder will be required to write, review and where appropriate approve validation protocols prior to execution, followed by report generation. The core activities will include qualification of:

  • Autoclaves (BSEN-285)
  • Dehydrogenation ovens
  • Extraction Tanks
  • Centrifuges
  • Vessels
  • Facilities and Utilities.

 The post holder will have the following duties and responsibilities;

  • Generate, review (technical) and execute validation protocols
  • Create validation reports
  • Using the Electronic Quality Management System (Master Control) to manage appropriate corrective action plans and report through the PBL non-conformance system, for failures/performance issues.
  • Write and review risk assessments
  • Manage work schedule as planned by the validation schedule co-ordinator
  • Coordinate contractor or permanent resources to deliver timely documentation in support of validation activities
  • Ensure validation procedures are aligned with regulatory requirements
  • Meet all internal regulatory training requirements (internal training provided)

 

We are looking for someone with the following skills, knowledge and experience;

 Essential

Degree or equivalent higher education qualification

Minimum 5 year’s hands-on experience of validation

Understanding of the validation life cycle

Equipment validation

Demonstrated skills and capability in planning, preparing, executing and reporting of validation activities

Good computer skills: Word, Excel.

Desirable

Biopharmaceutical experience

BSEN-285 – sterilisation, steam sterilisers, large sterilisers

Facilities and utilities validation

Risk based approach to validation

Datalogger (V2K) and Val Probe equipment and software

Cross functional communication skills

To apply for this position please submit a CV and cover letter using the criteria in the job description/person specification as sub-headings to identify how you meet each of the selection criteria and outline why you would like a career at Porton Biopharma Ltd.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer

To download the job description please click here

PBL539 QC Microbiologist

Salary: Circa £22,000.00 per annum, dependant on experience

Closing Date: 14th August 2020

Reference Number: PBL539

Job Summary...…….

The post holder will be part of the QC Bacteriology Technical Services team and assist with activities which include the following:

To undertake and perform microbiological QC analyses in the Quality Control Bacteriology Technical Services Unit, which provides specialist microbiological testing services in support of licensed pharmaceutical manufacture at PBL, Porton Down, in compliance with cGMP.

 The post holder will…………

  • Undertake and perform microbiological QC analyses in support of Porton Biopharma’s licensed production, service, validation and developmental programs.
  • Carry out all work in compliance with cGMP
  • Test microbiological samples from all stages of the production processes of licensed and developmental products and to assess the results against pre-set standards and specifications
  • Undertake identification of micro-organisms isolated from microbiological tests and samples
  • Record all information and data clearly and accurately
  • Pre-test media used within QC and Production against pre-set specifications
  • Maintain the Bacteriology Technical Services Culture Collection, media stocks, and necessary consumables to ensure the efficient running of the group
  • Safely operate, clean and maintain laboratory equipment to the required levels of cleanliness and operating standards
  • Provide cover for and assist the Environmental Monitoring team when required

 We are looking for……………….

An applicant who has good interpersonal skills and able to work as part of a team and is methodical and reliable with the ability to think clearly, the ability to learn and able to respond to changes in schedule and demands. The applicant will need to have knowledge and experience of microbiology gained in a laboratory or similar environment and ideally have experience of working in a Good Manufacturing Practice GMP or similarly regulated environment.

Key skills are:

  • Knowledge and experience of microbiology gained in a laboratory or similar environment.
  • An understanding of GMP and quality systems
  • Able to work methodically and to strict deadlines
  • To perform routine testing within the microbiology laboratory, on a day to day basis, of the Bacteriology Technical Services Unit.
  • Good understanding of QC microbiological assays and QC laboratory systems
  • Confident to train junior staff in processes and procedures

To apply for this position please submit a CV and cover letter using the criteria in the job description/person specification as sub-headings to identify how you meet each of the selection criteria and outline why you would like a career at Porton Biopharma Ltd.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer

To download the job description please click here

PBL568 Senior Production Technician FPP

Salary: Starting salary £21,000 per annum, plus 30% shift enhancement

Closing Date: 24th July 2020

Reference Number: PBL568

Job Summary…

This is a shift working role which will attract a salary enhancement once appointed. This Senior Production Technician post is located at Porton Down in the Fermentation Process Plant (FPP) current Good Manufacturing Practice (cGMP) pharmaceutical manufacturing facility. This facility produces therapeutic products by bacterial fermentation followed by initial phase downstream processing. Therapeutic products produced at Porton are licensed and marketed for worldwide distribution. The FPP is undergoing significant investment and expansion as production is being increased to meet product demand.

We are looking for…

An applicant who has GCSE’s in Maths, English and Science or equivalent qualifications. In addition, they should also be educated to a minimum of NVQ level 2 in a relevant subject or have significant equivalent proven experience. Candidates should have an interest in working within a manufacturing environment and with the Quality systems associated with cGMP manufacture. They should be able to communicate clearly, possessing good writing and data entry skills. Lastly applicants should be able to work effectively as part of a team, be proactive and able to work on their own initiative when required.

The post holder will…

Work a shift pattern which covers 24-hour, 7 days working. They will report to the Production Supervisor and will support the Production Supervisor to meet team targets by ensuring manufacturing operations are performed in a timely and compliant manner to cGMP requirements. This role will involve undertaking a varied range of tasks, from preparation and use of operational equipment such as large-scale fermenters and centrifuges, to preparation, completion, and review of Quality documentation. Full training will be provided.

Main Duties and Responsibilities include but not limited to;

  • Working in an automated chemical plant.
  • Operate plant and equipment using newly installed automated control systems.
  • Ensure that the various work areas are maintained at the highest state of readiness at all times.
  • Ensure that their daily activities are coordinated with other team members.
  • Work within a GMP quality system.
  • Ensure that documentation is completed within the legal frameworks.
  • Take responsibility for Non-Conformances, CAPA, Risk Assessments and Change Controls for the area and ensure SOPs and BMRs are available for use.

Successful applicants must either hold, or be capable of obtaining, a UK government security clearance at SC level.  To obtain clearance at this level you must have been resident in the UK for the last five years, and not lived abroad for more than six months out of the last twelve.

For further information or an informal discussion about the post, please contact:

Mark Poole (Unit Manager – Fermentation Production Plant)

Email mark.poole@portonbiopharma.com

Phone: 01980 612644

To apply for this position please submit a CV and cover letter using the criteria in the job description/person specification as sub-headings to identify how you meet each of the selection criteria and outline why you would like a career at Porton Biopharma Ltd.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer

 

To download the job description please click here

PBL592 Director of Quality

Salary: As Per Market

Closing Date: 28th August 2020

Reference Number: PBL592

An opportunity has arisen within Porton Biopharma Ltd for a Director of Quality. The role is focused on delivery of biopharmaceutical products within a highly regulated environment. Candidates must have a strong blend of strategic, operational and resource management skills, with a strong commercial focus.

Porton Biopharma Ltd manufactures two licensed biopharmaceutical products and is a medium sized company performing a range of process and analytical development, production, quality control and quality assurance activities. The company also undertakes contract manufacturing and development projects.

Reporting to the Managing Director, the post holder will have overall quality responsibility for all manufacturing activities and as part of the Executive Team will also play a leading role in the strategic development of the company and achievement of its business objectives.

The post holder will be a Quality professional from the pharmaceutical industry with extensive experience and knowledge of aseptic processing, quality systems and regulatory requirements. They will also be able to demonstrate sound corporate and commercial awareness. The ideal candidate will have proven leadership qualities including strategic influencing skills, political astuteness, inspiring change, drive for results and collaborative working.

If you are interested in exploring this opportunity further, it will be essential for you to have proven knowledge and expertise in the following specific areas:

  • Extensive management experience (in a commercial, regulated, pharmaceutical company)
  • Experience of implementing quality systems in a GxP environment
  • Extensive knowledge of US/EU GxP compliance regulations and industry practices
  • Experience of inspections and liaising with FDA, MHRA and other regulatory bodies
  • Excellent working knowledge of aseptic products and processes
  • Excellent leadership skills and able to communicate effectively across different cultures
  • Holder of a degree within a pharmaceutical, chemistry or life sciences field
  • Proven experience and capability in managing risk; track record of managing and delivering projects, particularly in the areas of quality and compliance.

For further information about the post, please contact the recruitment@portonbiopharma.com. Candidates must be eligible to work in the UK.

Applicants are strongly advised to use the criteria above (or as listed in the job description/ person specification) as sub-headings in their application to make it clear how they meet the requirements of the role.

Porton Biopharma Ltd promotes diversity in the workplace and is an equal opportunities employer

To download the job description please click here